In general, you can take what you’ve learned from playing Team Fortress 2 and translate it to Team Fortress Classic. They are the same 9 classes after all, and they have mostly the same loadouts, just with more shotguns. Some things will throw you for curveballs (I wrote a pretty extensive guide here) but in general you can guess what each class is about.
Except one.

TF2 will not prepare you in any way to start playing the TFC Combat Medic. Especially if you’ve played the TF2 Medic. Playing the combat medic like this will instantly label you as a TF2 immigrant who has never touched the game before. I was one of those once, but I persevered and now I consider myself a proficient TFC medic. Note that anyone who played TFC in its heyday could educate you better then me, but here’s what I’ve learned: